Lithium levels in tap water may be linked to an increased risk of autism spectrum disorder (ASD) in children born to pregnant women exposed to higher concentrations.
According to a recent study published in the journal JAMA Pediatrics, mothers who consumed tap water with higher lithium levels had a significantly higher risk of their offspring being diagnosed with ASD. The research found that children whose mothers drank water with lithium levels at or above 200 parts per billion (ppb) were more likely to receive an ASD diagnosis than those born to mothers drinking water with lower levels.
While the study's findings are intriguing, experts caution against drawing a direct causal link between lithium exposure and ASD. "The relationship between lithium exposure during pregnancy and autism is complex, and more research is needed," said Dr. Beate Ritz, co-author of the study.
Lithium is an alkali metal commonly found in food, ground water, and various industrial applications, including batteries, grease, and air conditioners. The US Environmental Protection Agency (EPA) does not regulate lithium levels in drinking water, but Denmark has implemented strict guidelines to minimize exposure.
Critics of the study argue that it lacks robust controls and fails to account for other potential environmental factors contributing to ASD risk, such as pesticides, air pollution, and phthalates. "The connection between environmental exposure and ASD is hard to prove," said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital.
Dr. Ritz acknowledged that the study did not establish a causal link between lithium exposure and ASD but emphasized the need for further research on drinking water contaminants affecting human brain development. "Any environmental contaminant that may affect the developing human brain deserves intense scrutiny," she said.
The implications of this study are complex, with some experts suggesting that guidelines for lithium levels in drinking water should be reconsidered to minimize potential risks. "If all these associations are valid, we will need to develop guidelines for lithium in drinking water that are maximally protective of the entire population," said Dr. David C. Bellinger, a professor of neurology and psychology at Harvard Medical School.
For now, more research is needed to fully understand the relationship between lithium exposure during pregnancy and ASD risk.
According to a recent study published in the journal JAMA Pediatrics, mothers who consumed tap water with higher lithium levels had a significantly higher risk of their offspring being diagnosed with ASD. The research found that children whose mothers drank water with lithium levels at or above 200 parts per billion (ppb) were more likely to receive an ASD diagnosis than those born to mothers drinking water with lower levels.
While the study's findings are intriguing, experts caution against drawing a direct causal link between lithium exposure and ASD. "The relationship between lithium exposure during pregnancy and autism is complex, and more research is needed," said Dr. Beate Ritz, co-author of the study.
Lithium is an alkali metal commonly found in food, ground water, and various industrial applications, including batteries, grease, and air conditioners. The US Environmental Protection Agency (EPA) does not regulate lithium levels in drinking water, but Denmark has implemented strict guidelines to minimize exposure.
Critics of the study argue that it lacks robust controls and fails to account for other potential environmental factors contributing to ASD risk, such as pesticides, air pollution, and phthalates. "The connection between environmental exposure and ASD is hard to prove," said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital.
Dr. Ritz acknowledged that the study did not establish a causal link between lithium exposure and ASD but emphasized the need for further research on drinking water contaminants affecting human brain development. "Any environmental contaminant that may affect the developing human brain deserves intense scrutiny," she said.
The implications of this study are complex, with some experts suggesting that guidelines for lithium levels in drinking water should be reconsidered to minimize potential risks. "If all these associations are valid, we will need to develop guidelines for lithium in drinking water that are maximally protective of the entire population," said Dr. David C. Bellinger, a professor of neurology and psychology at Harvard Medical School.
For now, more research is needed to fully understand the relationship between lithium exposure during pregnancy and ASD risk.